Publications by authors named "F Noto"
Background: Metabolic dysfunction-associated steatotic liver disease (MASLD) is a global epidemic. MASLD has a strong genetic component, and a common missense variant (rs2642438) in the mitochondrial amidoxime-reducing component 1 (MARC1) gene confers protection against its onset and severity. However, there are contrasting results regarding the mechanisms entangling this protection.
View Article and Find Full Text PDFBlood and airway eosinophilia represent markers for the endotype-driven treatment of allergic asthma. Little is known on mechanisms that link eosinophils and airway epithelial cells before and after these cells are infiltrated by eosinophils during allergic response. Given that innate immune mechanisms, mainly mediated by epithelial-derived cytokines (IL-33, IL-25, TSLP), induce eosinophil-maturing/attractive substances, we thought to evaluate the crosstalk between eosinophils and airway epithelial cells in the context of IL-33-mediated allergic inflammation.
View Article and Find Full Text PDFArticle Synopsis
- Eosinophils, when activated by the alarmin IL-33, produce extracellular vesicles (EV) that show potential anti-tumor effects, contrasting with those activated by IL-5.
- Incorporating these IL-33-activated eosinophil-derived EV (Eo33-EV) into tumor cells leads to increased expression of genes that promote cell cycle arrest and reduces tumor growth and metastasis.
- RNA sequencing highlights that Eo33-EV are enriched with tumor suppressor genes and pathways that enhance an epithelial phenotype, indicating their potential role in cancer therapy through cell reprogramming.
Article Synopsis
- The study investigates the distinct regions of the germinal center (GC)—the dark zone (DZ) and light zone (LZ)—which are crucial for B-cell expansion and antibody maturation, yet lack a clear understanding of their immune composition differences.
- Researchers discovered specific DNA damage responses and chromatin features that explain why T-cells are excluded from the DZ region, providing insights into its immune-repulsive characteristics.
- The findings highlight the role of the ATR kinase in regulating responses in the DZ, suggesting that targeting ATR could enhance immunotherapy effectiveness for aggressive types of lymphoma like Diffuse Large B-cell Lymphomas (DLBCL).
Objective: Metabolic dysfunction-associated steatotic liver disease (MASLD) is a global health concern with no effective and specific drug treatment available. The rs2642438 minor allele in mitochondrial amidoxime-reducing component 1 (MARC1) results in an aminoacidic substitution (p.Ala165Thr) and associates with protection against MASLD.
View Article and Find Full Text PDF