Publications by authors named "F Northington"
Background: Intestinal fatty acid binding protein (I-FABP) is an intestinal epithelial protein detectable in infants with necrotizing enterocolitis (NEC). The longitudinal behavior of I-FABP following NEC or its association with gastrointestinal or neurodevelopmental outcomes is unknown.
Methods: In this secondary analysis of the Preterm Erythropoietin Neuroprotection Trial, we compared infants with and without NEC.
Article Synopsis
- * Traditional treatment methods like therapeutic hypothermia are often ineffective in these regions due to resource limitations.
- * Intranasal therapies offer a promising alternative due to their low cost and ease of administration, but further research and human clinical trials are needed to develop these treatments for HIE.
Hypoxic-ischemic encephalopathy (HIE) in neonates causes mortality and neurologic morbidity, including poor cognition with a complex neuropathology. Injury to the cholinergic basal forebrain and its rich innervation of cerebral cortex may also drive cognitive pathology. It is uncertain whether genes associated with adult cognition-related neurodegeneration worsen outcomes after neonatal HIE.
View Article and Find Full Text PDFThe mild hypothermia response (MHR) maintains organismal homeostasis during cold exposure and is thought to be critical for the neuroprotection documented with therapeutic hypothermia. To date, little is known about the transcriptional regulation of the MHR. We utilize a forward CRISPR-Cas9 mutagenesis screen to identify the histone lysine methyltransferase SMYD5 as a regulator of the MHR.
View Article and Find Full Text PDFArticle Synopsis
- * The study used DKI to analyze brain injury related to hypoxia and ischemia in mice, indicating cellular swelling and changes in permeability through specific imaging results.
- * Initial tests of DKI in stroke patients show promise for identifying damaged areas in the brain, highlighting its potential as a clinical tool for assessing tissue health and recovery.