Publications by authors named "F Noizat-Pirenne"
The SARS-CoV-2 Omicron variant can escape neutralization by vaccine-elicited and convalescent antibodies. Memory B cells (MBCs) represent another layer of protection against SARS-CoV-2, as they persist after infection and vaccination and improve their affinity. Whether MBCs elicited by mRNA vaccines can recognize the Omicron variant remains unclear.
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- Memory B cells are crucial for fighting viruses, but their specific role in SARS-CoV-2 infection has been unclear until now.
- A study tracked the B cell response in COVID-19 patients for 6 months, finding that early B cell activation led to strong antibody production and ongoing immune response.
- The research shows that specific memory B cells evolved with somatic mutations over time, indicating a persistent immune activation that could help provide long-term protection against SARS-CoV-2.
Background: Transfusion-transmitted bacterial infections (TTBIs) are the main residual infectious complications of transfusions. Escherichia coli and platelet (PLT) concentrates may be epidemiologically associated, leading to severe, if not lethal, TTBIs. We investigated the genotypic and phenotypic reasons for this clinically deleterious combination.
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