Unbiased Drug Target Prediction Reveals Sensitivity to Ferroptosis Inducers, HDAC and RTK Inhibitors in Melanoma Subtypes.

Background: The utilization of PD1 and CTLA4 inhibitors has revolutionized the treatment of malignant melanoma (MM). However, resistance to targeted and immune-checkpoint-based therapies still poses a significant problem.

Objective: Here, we mine large-scale MM proteogenomic data to identify druggable targets and forecast treatment efficacy and resistance.

Review Article: Current Concepts in the Treatment of Congenital Clubfoot.

Congenital clubfoot is a complex, frequent deformity that can be challenging even in experienced hands. The Ponseti method remains universally accepted as the gold standard for treatment, and excellent outcomes are within expectations in most cases with appropriate technical management. Recurrences continue to be a problem and are mainly associated with non-compliance with orthosis use.

Regulation of abscisic acid receptor mRNA stability: involvement of microRNA5628 in PYL6 transcript decay.

Phytohormone signaling is fine-tuned by regulatory feedback loops. The phytohormone abscisic acid (ABA) plays key roles in plant development and abiotic stress tolerance. PYRABACTIN RESISTENCE 1/PYR1-LIKE/REGULATORY COMPONENT OF ABA RECEPTOR (PYR/PYL/RCAR) receptors sense ABA, and in turn, ABA represses their expression.