Highly accurate real-space electron densities with neural networks.

Variational ab initio methods in quantum chemistry stand out among other methods in providing direct access to the wave function. This allows, in principle, straightforward extraction of any other observable of interest, besides the energy, but, in practice, this extraction is often technically difficult and computationally impractical. Here, we consider the electron density as a central observable in quantum chemistry and introduce a novel method to obtain accurate densities from real-space many-electron wave functions by representing the density with a neural network that captures known asymptotic properties and is trained from the wave function by score matching and noise-contrastive estimation.

Reinforcement Learning Optimization of the Charging of a Dicke Quantum Battery.

Quantum batteries are energy-storing devices, governed by quantum mechanics, that promise high charging performance thanks to collective effects. Because of its experimental feasibility, the Dicke battery-which comprises N two-level systems coupled to a common photon mode-is one of the most promising designs for quantum batteries. However, the chaotic nature of the model severely hinders the extractable energy (ergotropy).

Unveiling adipose populations linked to metabolic health in obesity.

Precision medicine is still not considered as a standard of care in obesity treatment, despite a large heterogeneity in the metabolic phenotype of individuals with obesity. One of the strongest factors influencing the variability in metabolic disease risk is adipose tissue (AT) dysfunction; however, there is little understanding of the link between distinct cell populations, cell-type-specific transcriptional programs, and disease severity. Here, we generated a comprehensive cellular map of subcutaneous and visceral AT of individuals with metabolically healthy and unhealthy obesity.

Sustained intermittent and continuous isometric muscle actions induce different levels of fatigue for the same force-time integral.

Introduction: The aim was to compare the fatiguing effects induced by continuous (CONT) and intermittent (INT) tasks of an identical duration by equating the force-time integral.

Method: ː Fourteen men performed two sequences (4 blocks of 378s) of contractions (CONT or INT) of the quadriceps femoris. The CONT contraction of 378s corresponded to 10% of the maximum voluntary muscle contraction (MVC).

Thyroid hormones are required for thermogenesis of beige adipocytes induced by Zfp423 inactivation.

The significance of thyroid hormones (THs) in beige adipocyte thermogenesis remains incompletely understood. We previously reported that THs directly regulate the expression of zinc-finger protein 423 (ZFP423), an anti-thermogenic factor, in adipose tissue. This study investigates the interaction between THs and adrenergic signaling in regulating thermogenic capacity and activation of beige adipocytes formed in response to Zfp423 deletion.