Publications by authors named "F Njiokou"
Long-term impact of exposure to Royal Guard, a pyriproxyfen-based bed net, on pyrethroid-resistant malaria vectors from Cameroon using DNA-based metabolic resistance markers.
Pest Manag Sci
January 2025
Background: Escalating pyrethroid resistance in malaria vectors highlights the urgency of implementing new control tools incorporating non-pyrethroid molecules. Here, using DNA-based metabolic resistance markers, we assessed the efficacy of the dual active ingredients net Royal Guard against pyrethroids-resistant malaria vectors in Cameroon, establishing its long-term impact on mosquitoes' life traits after exposure.
Results: Cone assays revealed low efficacy of Royal Guard against field Anopheles populations.
Article Synopsis
- - The study investigates the prevalence of a specific bacterium in mosquito populations as a potential method for controlling malaria, focusing on co-infections with the malaria parasite in Cameroon.
- - Researchers collected and analyzed 864 adult mosquitoes from two locations during both dry and wet seasons, using real-time qPCR to assess bacterial and malaria parasite densities.
- - Results indicated a higher prevalence of the bacterium in one species of mosquito compared to another, influenced by seasonal changes, but no correlation was found between the bacterium and malaria infections, suggesting the need for further experimental studies.
Article Synopsis
- - This study investigates the gut microbiota of the blackfly Simulium damnosum s.l. to understand its role in the transmission of the parasite Onchocerca volvulus, which causes river blindness.
- - Adult female blackflies were collected from various regions in Cameroon, and their gut microbiota was analyzed using advanced sequencing techniques to identify dominant bacterial taxa and assess microbiota diversity.
- - Findings revealed significant variations in the gut microbiota related to certain factors like the blackfly's reproductive status and geographic origin, with specific bacteria associated with the absence of O. volvulus infection, indicating a complex relationship between the microbiota and parasite transmission.
Novel vector control tools against African trypanosomiases require a deep understanding of the factors driving tsetse vector fitness or population resilience in their ecosystems. Following evidence of microbiota-mediated host fitness or traits shaping, including insecticide resistance in arthropod populations, we undertook a comparative study of the microbiota in wild-caught tsetse flies during vector control with deltamethrin-impregnated traps called Tiny Targets. The bacterial microbiome composition of tsetse flies collected before and after 6, 12, and 18 months of vector control were characterized using high-throughput sequencing of the V3-V4 hypervariable region of the bacterial 16S rRNA gene and compared.
View Article and Find Full Text PDFArticle Synopsis
- Surveillance of "silent" human African Trypanosomiasis (HAT) foci in Cameroon is crucial for meeting the World Health Organization's goal of interrupting disease transmission by 2030, prompting a study on trypanosome species present in Bafia and Manoka island.
- Using georeferenced traps, researchers captured 1683 tsetse flies and employed molecular methods to identify trypanosome species and examine blood meal sources, highlighting areas at high risk for transmission.
- The study found a notable difference in tsetse fly density and infection rates between the two regions, with a 7.34% overall infection rate and mixed infections primarily involving Trypanozoon and T. congolense