Publications by authors named "F Nassiri"
Article Synopsis
- - The study validates a new DNA methylation-based predictor for meningiomas that has been enhanced for use with modern methylation arrays and shows improved accuracy over the standard 2021 WHO grading system.
- - It uses data from 1,347 meningioma cases, including prospective cases and an external cohort, demonstrating that both the new and original models effectively predict early postoperative recurrence, especially within specific risk subgroups.
- - The new predictor, which is simpler with fewer features, allows for better clinical decision-making, including the use of adjuvant radiotherapy for high-risk patients, and is available as an easy-to-use tool for improved patient stratification in clinical trials.
Introduction: Subdural haematomas (SDHs), acute or chronic, are common neurosurgical diagnoses. These problems can occur among patients requiring direct oral anticoagulation (DOAC) for atrial fibrillation. There are currently no guidelines regarding the optimal timing to resume anticoagulation for these patients after SDH.
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- * Recent research indicates that spinal meningiomas have unique subtypes and genetic diversity, differing from intracranial meningiomas, even within the same WHO grades.
- * The review emphasizes the need for more studies to connect molecular, genetic, and imaging data to clinical outcomes, aiming to improve patient prognosis and treatment management.
Article Synopsis
- Brain metastases (BMs) are the most common and lethal brain tumors, primarily originating from lung adenocarcinoma (LUAD), yet reliable predictors for their development are currently lacking.
- Researchers analyzed 402 tumor and plasma samples from LUAD patients to create a predictive model based on DNA methylation signatures, combining it with clinical data for personalized risk assessments of developing BMs.
- The study also identified unique genetic markers and immune cell changes that could aid in early detection of BMs through non-invasive tests, enhancing the potential for targeted and effective treatments.