Publications by authors named "F Nasri"
Harnessing the power of the immune system to target cancer cells is one of the most appealing approaches for cancer therapy. Among these immunotherapies, messenger ribonucleic acid (mRNA) cancer vaccines are worthy of consideration, as they have demonstrated promising results in clinical trials. These vaccines have proven to be safe and well-tolerated.
View Article and Find Full Text PDFThis study aimed to characterize two types of postbiotics from Lactobacillus acidophilus LA-5 prepared in De Man, Rogosa, and Sharpe (MRS-Pb) and UF cheese whey (W-Pb). We compared the chemical compositions, functional properties, and toxicities of the prepared probiotics. Assessments included antimicrobial and antioxidant activities, total and individual phenolic compounds, volatile compounds, individual free amino acids, and organic acid contents.
View Article and Find Full Text PDFTrastuzumab is primarily utilized in the treatment of patients with human epidermal growth factor receptor 2 (HER2) positive breast cancer. This study aimed to investigate the incidence of cardiac toxicity associated with trastuzumab in HER2-positive breast cancer patients at Iran Hospital in 2023, as well as the factors influencing this toxicity. In this cross-sectional study, 200 patients diagnosed with HER2-positive breast cancer and receiving trastuzumab were included.
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- Noise-induced cochlear synaptopathy leads to the permanent loss of synapses between inner hair cells (IHCs) and spiral ganglion neurons (SGNs) without affecting overall hearing thresholds.
- In experiments with C57BL/6 N mice exposed to various noise levels, significant changes in auditory brainstem responses (ABRs) were observed, indicating loss of IHC synaptic connections and impaired hearing ability over time.
- The study revealed that while the number of synaptic pairs decreased significantly, the IHC postsynapses were more resilient than the presynaptic ribbons, highlighting the vulnerability of these synapses to noise trauma at high decibel levels.
Purpose: The diagnosis of idiopathic intracranial hypertension (IIH) is often challenging in patients who do not present with classic symptoms. Brain MRI can play a pivotal role, as several imaging findings, such as an empty sella appearance (ESA), have been shown to be associated with IIH. Yet, none of the MRI signs have been shown to have a high sensitivity and specificity.
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