Publications by authors named "F Nagel"
Objectives: The goal of this project was to assess the efficacy of a reoperative frozen elephant trunk (FET) operation for treating residual type A aortic dissections.
Methods: Between April 2015 and October 2023, a total of 237 patients underwent elective redo surgical aortic arch replacement via the FET technique to treat residual type A aortic dissection in 11 European aortic centres. Data were pooled and analysed retrospectively.
Article Synopsis
- This study evaluated the photoreceptor mosaic in patients with idiopathic full thickness macular holes before and after surgery using adaptive optics imaging.* -
- Conducted at the Kensington Eye Institute, the research excluded patients with certain conditions and involved detailed measurements of cone density and regularity in the retina.* -
- Results showed a significant decrease in cone density and changes in spacing and dispersion three months post-surgery, demonstrating the effectiveness of adaptive optics for assessing retinal health.*
Article Synopsis
- - During Hedgehog (Hh) signaling, the SMOOTHENED (SMO) receptor interacts with GLI transcription factors by blocking the activity of a key enzyme, protein kinase A (PKA-C).
- - The study reveals that GPCR kinase 2 (GRK2) moves to the primary cilium upon SMO activation, leading to SMO phosphorylation and facilitating its direct interaction with PKA-C.
- - This research highlights the essential role of GRK2 in Hh signaling, suggesting that GRKs may be important for direct interactions between GPCRs and other cellular proteins.
Background: Our patient presented with acute back pain and dyspnea, without neurological symptoms. The computed tomography (CT) scan showed a circumferent rupture of the ascending aortic intima which was invaginated in the arch and descending aorta.
Case Presentation: A 54-year-old male patient was diagnosed with a Type A aortic dissection.
Agonist-induced phosphorylation is a crucial step in the activation/deactivation cycle of G protein-coupled receptors (GPCRs), but direct determination of individual phosphorylation events has remained a major challenge. We have recently developed a bead-based immunoassay for the quantitative assessment of agonist-induced GPCR phosphorylation that can be performed entirely in 96-well plates, thus eliminating the need for western blot analysis. In the present study, we adapted this assay to three novel phosphosite-specific antibodies directed against the neurokinin 1 (NK1) receptor, namely pS338/pT339-NK1, pT344/pS347-NK1, and pT356/pT357-NK1.
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