Publications by authors named "F Nabeeh Jaafar"
Purpose: Children with epilepsy are at an increased risk of developing psychiatric comorbidities, which exacerbate the overall disease burden. However, these disorders are often underreported in developing countries. This study, conducted in a developing country, aims to evaluate the frequency of psychiatric disorders and associated factors in a large cohort of children with epilepsy.
View Article and Find Full Text PDFBackground: Vaping is touted as a safer alternative to traditional cigarette smoking, but the full spectrum of harm reduction versus comparable risk remains unresolved. Elevated bioavailability of nicotine in vape aerosol together with known risks of nicotine exposure may result in previously uncharacterized cardiovascular consequences of vaping. The objective of this study is to assess the impact of nicotine exposure via vape aerosol inhalation upon myocardial response to infarction injury.
View Article and Find Full Text PDFArticle Synopsis
- Phoenixin (PNX) is a neuropeptide that significantly influences metabolism and reproduction, playing a role in energy homeostasis, glucose, lipid metabolism, and mitochondrial function.
- PNX is primarily found in the hypothalamus and is involved in reproductive hormone regulation, as well as being present in other tissues like the heart and pancreas, indicating its widespread metabolic control.
- The peptide acts through G protein-coupled receptor 173 (GPR173) and may have therapeutic potential for managing conditions like obesity, type 2 diabetes, and infertility, making further research crucial for developing treatment strategies.
Ovarian cancer (OC) remains the deadliest gynecological malignancy, with alarming projections indicating a 42% increase in new cases and a 51% rise in mortality by 2040. This review explores the challenges in OC treatment, focusing on chemoresistance mechanisms and the potential of extracellular vesicles (EVs) as drug delivery agents. Despite advancements in treatment strategies, including cytoreductive surgery, platinum-based chemotherapy, and targeted therapies, the high recurrence rate underscores the need for innovative approaches.
View Article and Find Full Text PDFObjective: Previous studies assessing factors associated with drug-resistant epilepsy (DRE) were constrained by their amalgamation of all epilepsy syndromes in their analyses and the absence of uniform criteria for defining DRE. Our objective was to identify predictors of DRE among the four primary childhood epilepsy syndrome groups within a cohort of children with new onset seizures, using the International League Against Epilepsy (ILAE) definition of DRE and the recent classification of epilepsies.
Methods: This is a prospective study of 676 children with new onset seizures initiated on antiseizure medication.