Endocrine disrupting chemicals during diet-induced weight loss - A post-hoc analysis of the LOWER study.

The link between exposure to endocrine disrupting chemicals (EDCs) and the rapid increase in prevalence of obesity has recently been suggested. However, the magnitude and health impact of EDC exposure in at-risk populations remain largely unclear. In this study, we investigated the effect of a dietary intervention driven reduction in adipose tissue on the magnitude of urinary EDC exposure and mobilization, and whether higher EDC exposure leads to impaired weight loss in obese individuals.

Relatively high-protein or 'low-carb' energy-restricted diets for body weight loss and body weight maintenance?

Background: 'Low-carb' diets have been suggested to be effective in body weight (BW) management. However, these diets are relatively high in protein as well.

Objective: To unravel whether body-weight loss and weight-maintenance depends on the high-protein or the 'low-carb' component of the diet.

Patient preference and acceptability of calcium plus vitamin D3 supplementation: a randomised, open, cross-over trial.

Unlabelled: Preference for a drug formulation is important in adherence to long-term medication for chronic illnesses such as osteoporosis. We investigated the preference for and acceptability of chewable tablet containing calcium and vitamin D (Calci Chew D(3), Nycomed) compared to that of a sachet containing calcium and vitamin D(3) (Cad, Will-Pharma). This open, randomised, cross-over trial was set up to compare the preference and acceptability of two calcium plus vitamin D(3) formulations (both with 500 mg calcium and 400/440 IU vitamin D3), given twice a day in patients with osteoporosis.

Bone mass in women with primary biliary cirrhosis: the relation with histological stage and use of glucocorticoids.

To assess the impact of primary biliary cirrhosis on bone mass in general and the relative importance of the stage of the liver disease and of treatment with glucocorticoids for the possible development of osteoporosis, bone mineral mass was measured by single and dual photon absorptiometry in 55 unselected female patients with longstanding primary biliary cirrhosis. Although most of the patients had a bone mineral density within the normal range, the bone mineral densities of the lumbar spine and distal and proximal forearm were 8% (P less than 0.004), 8% (P less than 0.