Evaluating the Immunoprotective and Diagnostic Potential of Schistosoma mansoni Epitopes from Sm050890 and Sm141290 Proteins Identified Through Reverse Vaccinology.

Purpose: Schistosomiasis remains a parasitic disease affecting millions of people worldwide, requiring interventions like vaccination. In previous work, our group used reverse vaccinology to identify two epitopes from the Schistosoma mansoni proteins, Sm050890 (44-58) and Sm141290 (225-239). This study evaluated the immune response profile and protection induced by peptides, as a mixture of immunogens, in murine vaccination trials.

Cymbopogon citratus showing nematicidal activity against Heligmosomoides polygyrus bakeri.

This paper describes a novel in vivo study of Cymbopogon citratus (lemon grass) to assess its anthelmintic activity. To this end, C57BL/6 mice were separated into three groups: G1: uninfected; G2: negative control infected with Heligmosomoides polygyrus bakeri and administered with 3% dimethyl sulfoxide (DMSO); and G3: infected with H. polygyrus bakeri and treated with C.

The problem of multiple adjustments in the assessment of minimal clinically important differences.

Introduction: Anthropometric, demographic, genetic, and clinical features may affect cognitive, behavioral, and functional decline, while clinical trials seldom consider minimal clinically important differences (MCIDs) in their analyses.

Methods: MCIDs were reviewed taking into account features that may affect cognitive, behavioral, or functional decline in clinical trials of new disease-modifying therapies.

Results: The higher the number of comparisons of different confounders in statistical analyses, the lower values will be significant.

Exploring risk factors linked to canine lymphoma: a case-control study.

Environmental factors, largely influenced by human behavior, account for approximately 80% of malignant tumors. Risk factors associated with non-Hodgkin's lymphoma (NHL) have been identified in various countries among both humans and domestic animals. This study aimed to investigate potential risk factors for NHL in dogs residing in the district of Porto, Portugal.

Knowledge of gross human anatomy among Brazilian physical education students: A cross-sectional study.

Background: Gross human anatomy is essential in undergraduate programs across biological and health sciences. While extensive literature explores medical students' knowledge in this area, studies on non-medical students, particularly those in physical education, are scarce.

Objective: This study assessed the anatomy knowledge among Brazilian physical education students and explored differences based on employment status, type of class instruction (face-to-face vs.