Publications by authors named "F N Corra"

Altered expression of circular RNAs (circRNAs) has previously been investigated in breast cancer. However, little is known about the effects of drugs on their regulation and relationship with the cognate linear transcript (linRNA). We analyzed the dysregulation of both 12 cancer-related circRNAs and their linRNAs in two breast cancer cell lines undergoing various treatments.

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The role of transglutaminase type 2 in cell physiology is related to protein transamidation and signal transduction (affecting extracellular, intracellular and nuclear processes) aided by the expression of truncated isoforms and of two lncRNAs with regulatory functions. In breast cancer TG2 is associated with disease progression supporting motility, epithelial-mesenchymal transition, invasion and drug resistance. The aim of his work is to clarify these issues by emphasizing the interconnections among variants and transcription factors associated with an aggressive phenotype, in which the truncated TGH isoform correlates with malignancy.

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Article Synopsis
  • The study focused on ultra-conserved regions (UCRs) in the human genome and their potential relationship with microRNAs (miRNAs) in cancer tissues.
  • Researchers analyzed over 6000 samples and found that certain non-coding RNAs were negatively co-regulated with miR-221, particularly investigating its role in the cell cycle in breast cancer.
  • In vitro experiments indicated that specific T-UCRs, like uc.183, uc.110, and uc.84, were mutually exclusive with miR-221, and anticancer drugs affected T-UCR expression without changing miR-221 levels.
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Due to their unique properties, perfluorinated substances (PFAS) are widely used in multiple industrial and commercial applications, but they are toxic for animals, humans included. This review presents some available data on the PFAS environmental distribution in the world, and in particular in Europe and in the Veneto region of Italy, where it has become a serious problem for human health. The consumption of contaminated food and drinking water is considered one of the major source of exposure for humans.

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Article Synopsis
  • The study focuses on purifying and characterizing Cu,Zn superoxide dismutase (SOD) from an Antarctic fish species that is crucial to the local food chain.
  • Researchers compared the amino acid sequence of this protein with those from other vertebrates, finding notable similarities and unique adaptations related to cold environments.
  • The findings provide insights into the evolutionary history and gene expression of antioxidant enzymes in this fish family, marking a significant step in understanding how these organisms cope with oxidative stress.
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