Publications by authors named "F Mwale"
Article Synopsis
- - The study investigates the role of periostin (POSTN) in osteoarthritis (OA), finding it is increased in patients and linked to inflammation and cartilage breakdown, suggesting it could be a target for therapy.
- - Link N (LN), a peptide from link protein, is shown to have anabolic properties and can reduce inflammation and degradation in cartilage, leading the researchers to explore its effects on POSTN expression.
- - Experimental results reveal that LN can decrease POSTN expression and disrupt its signaling in chondrocytes, indicating it has potential as a therapeutic agent in treating OA by targeting POSTN.
Article Synopsis
- Intervertebral disc degeneration and pain are linked to the activation of the NLRP3 inflammasome and the processing of IL-1β, which involves Toll-like receptor stimulation and the CD14 receptor.
- The peptide Short Link N (sLN) has shown promise in reducing inflammation and pain in disc cells, but its exact mechanisms of action are not fully understood.
- This study found that sLN inhibited the activation of NFκB and Caspase-1, leading to lower levels of IL-1β, and demonstrated a direct interaction between sLN and CD14, suggesting sLN could be a potential treatment for disc-related pain.
Applying cold to a bone injury can aid healing, though its mechanisms are complex. This study investigates how cold therapy impacts bone repair to optimize healing. Cold was applied to a rodent bone model, with the physiological responses analyzed.
View Article and Find Full Text PDFFracture healing, a critical and complex biological process, often presents challenges in clinical practice with the current standards failing to fully address the medical needs for rapid and effective recovery. In this work, a localized cold therapy is investigated as an alternative approach to expedite bone healing. We hypothesized that optimized cold application can enhance bone healing within a fracture model by inducing hypoxia, leading to accelerated angiogenesis along with improved osteogenesis.
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