Publications by authors named "F Multinu"
Objective: The optimal treatment for patients with cervical stromal invasion (CSI) in endometrial cancer (EC) remains unclear. We aimed to test the prognostic role of molecular classification in EC patients with CSI.
Methods: A retrospective, multicenter review of EC patients with CSI was performed.
Article Synopsis
- The study aimed to determine the recurrence rate of para-aortic lymph nodes in patients with early-stage cervical cancer who did not have surgical staging for these nodes while undergoing radical surgery.
- A total of 432 patients were included, with a focus on various stages of cervical cancer and the follow-up revealed that only 0.5% of patients experienced recurrence in the para-aortic lymph nodes.
- The overall 5-year recurrence-free survival rate for the cohort was found to be 90%, suggesting that para-aortic lymphadenectomy may not be necessary in all early-stage cases.
Article Synopsis
- The study aimed to assess the frequency of lower extremity lymphedema in patients with early-stage endometrial cancer who had laparoscopic surgery using the sentinel lymph node (SLN) approach.
- A total of 239 patients were surveyed, revealing that those who underwent hysterectomy with SLN had a significantly lower lymphedema rate (21.4%) compared to those who had systematic lymphadenectomy (44.6%).
- The results support the use of SLN mapping in laparoscopic surgery for endometrial cancer, as it reduces the risk of lymphatic complications while maintaining diagnostic effectiveness.
Objective: To assess the distribution of molecular classes and their impact on the risk of recurrence in endometrial cancer patients with lymph node metastasis at the time of primary surgery.
Methods: Endometrial cancer patients with lymph node micrometastasis or macrometastasis (International Federation of Gynecology and Obstetrics (FIGO) 2009 stage IIIC) after surgical staging at five referral centers worldwide from October 2013 to September 2022 who underwent molecular classification were identified. Endometrial cancers were categorized into four molecular classes: POLE mutated, mismatch repair deficient, p53 abnormal, and no specific molecular profile.