Publications by authors named "F Mulas"
Objective: To evaluate the technical accuracy, inheritance, and pathogenicity of small copy number variants (CNVs) detected by a targeted next-generation sequencing-based preimplantation genetic testing for aneuploidy (PGT-A) platform.
Design: Retrospective observational study performed between 2020 and 2022.
Setting: Clinic.
Article Synopsis
- Preliminary studies indicate that extracorporeal CO removal (ECCOR) combined with Continuous Renal Replacement Therapy (CRRT) may help patients with moderate ARDS and acute renal failure, especially in the context of COVID-19, but more research is needed.
- This study compared moderate ARDS patients with COVID-19 who received the ECCOR+CRRT treatment to a historical control group without COVID-19, using metrics like driving pressure to evaluate effectiveness.
- Results showed a significant reduction in driving pressure in COVID-19 patients after treatment, but no differences in 28-day mortality or mechanical ventilation duration when compared to the control group, suggesting ECCOR+CRRT could be beneficial for managing respiratory pressures in these patients.
Methods for inactivation of seafood Anisakis larvae and prevention of human anisakiasis: a mini-review.
Eur Rev Med Pharmacol Sci
June 2023
Anisakiasis is an arising zoonosis induced by parasitic nematodes belonging to the family Anisakidae. Anisakiasis is often caused by the ingestion of larval nematodes in uncooked or minimally processed seafood dishes, which are regularly consumed by humans. Significant potential sources of infection are raw fish (e.
View Article and Find Full Text PDFAdaptation of the islet β cell insulin-secretory response to changing insulin demand is critical for blood glucose homeostasis, yet the mechanisms underlying this adaptation are unknown. Here, we have shown that nutrient-stimulated histone acetylation plays a key role in adapting insulin secretion through regulation of genes involved in β cell nutrient sensing and metabolism. Nutrient regulation of the epigenome occurred at sites occupied by the chromatin-modifying enzyme lysine-specific demethylase 1 (Lsd1) in islets.
View Article and Find Full Text PDFArticle Synopsis
- - Attention deficit hyperactivity disorder (ADHD) is the most common neurodevelopmental disorder seen in pediatric healthcare, leading to increased awareness and earlier diagnoses.
- - Timely and effective treatment relies on individualized assessments using neuropsychological studies and understanding the neuroanatomical and neurobiochemical aspects of ADHD.
- - The best treatment strategy combines both medication and cognitive behavioral therapies, highlighting a multimodal approach for optimal results.