Publications by authors named "F Motolese"

Article Synopsis
  • - There is a recognized connection between cerebrovascular disease and chronic kidney disease, where brain issues in kidney patients may not show symptoms or could be detected through imaging tests.
  • - Initial brain damage in these patients is from small vessel issues, leading to various structural and microstructural changes visible on MRIs, which can increase risks for stroke and cognitive problems like dementia.
  • - Patients with advanced kidney disease, especially those on dialysis, face higher risks of serious brain complications, yet there are no clear guidelines for preventing these issues, highlighting the need for more research on using neuroimaging in diagnosis.
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Objective: The mechanisms of actions of transcutaneous auricular vagus nerve stimulation (taVNS) are still unclear, however the activity of the cholinergic system seems to be critical for the induction of VNS-mediated plasticity. Transcranial Magnetic Stimulation (TMS) is a well-suited, non-invasive tool to investigate cortical microcircuits involving different neurotransmitters. Herein, we evaluated the effect of taVNS on short-latency afferent inhibition (SAI), a TMS paradigm specifically measuring cholinergic neurotransmission.

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Article Synopsis
  • Alzheimer's disease is linked to abnormal deposits of beta-amyloid and tau proteins, and blood biomarkers may help detect them; decreased kidney function could impact how these biomarkers are cleared from the body.
  • This study analyzed the relationship between kidney function, blood biomarker levels, and cognitive impairment in Alzheimer’s patients without chronic kidney disease, using retrospective data and blood samples to measure various protein levels.
  • Results showed that only plasma levels of Aβ42 were significantly affected by kidney function, suggesting that renal function influences the clearance of this particular protein, while other Alzheimer's biomarkers remained unaffected.
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