Oral candidiasis is an opportunistic fungal infection in the oral cavity caused by an overgrowth of Candida species, especially Candida albicans. Various herbal agents have been designed to target Candida albicans. The aim of this study was to evaluate the antifungal activity of Jaftex mouthwash and nystatin suspension on the growth of Candida albicans.
View Article and Find Full Text PDFWe investigate the effect of filament-obstacle interactions on the force-velocity relation of growing biopolymers, via calculations explicitly treating obstacle diffusion and stochastic addition and subtraction of subunits. We first show that the instantaneous subunit on- and off-rates satisfy a rigorous thermodynamic relationship determined by the filament-obstacle interaction potential, which has been violated by several calculations in the literature. The instantaneous rates depend not only on the average force on the obstacle but also on the shape of the potential on the nanometer length scale.
View Article and Find Full Text PDFThe process by which actin polymerization generates pulling forces in cellular processes such as endocytosis is less well understood than pushing-force generation. To clarify the basic mechanisms of pulling-force generation, we perform stochastic polymerization simulations for a square array of polymerizing semiflexible actin filaments, having different interactions with the membrane. The filaments near the array center have a strong attractive component.
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