Publications by authors named "F Moreno Macian"
Article Synopsis
- Chaperone-mediated autophagy (CMA) is important for cellular health, but its activity decreases with age, particularly in the immune system due to lower levels of LAMP2A.
- * Researchers found that increasing LAMP2A in T cells can counteract some age-related declines in their function and improve immune responses.
- * The study suggests that maintaining CMA activity might be a promising strategy to enhance T cell effectiveness in older individuals, potentially using small molecule activators.
Objective: Diffuse central nervous system manifestations, referred to as neuropsychiatric lupus (NPSLE), are observed in 20-40% of lupus patients and involve complex mechanisms that have not yet been adequately elucidated. In murine NPSLE models, choroid plexus (ChP)-infiltrating T cells have not been fully evaluated as drivers of neuropsychiatric disease.
Method: Droplet-based single-cell transcriptomic analysis (single-cell RNA sequencing) and immune T-cell receptor profiling were performed on ChP tissue from MRL/lpr mice, an NPSLE mouse model, at an 'early' and 'late' disease state, to investigate the infiltrating immune cells that accumulate with NPSLE disease progression.
Background: The Alberta Stroke Program Early CT scan Score (ASPECTS) is a reliable imaging biomarker of infarct extent on admission but the value of 24-hour ASPECTS evolution in day-to-day practice is not well studied, especially after successful reperfusion. We aimed to assess the association between ASPECTS evolution after successful reperfusion with functional and safety outcomes, as well as to identify the predictors of ASPECTS evolution.
Methods: We used data from an ongoing prospective multicenter registry.
Background & Purpose: Carotid Web (CaW) is a growingly recognized cause of ischemic stroke, associated with a high recurrence risk. Several therapeutic strategies have been proposed as a tertiary prevention including carotid stenting, endarterectomy and antithrombotic medications. Among these, carotid stenting with dual-layer stent may be promising to adequately cover the focal arterial dysplasia.
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- Chaperone-mediated autophagy is like a cleanup crew in our cells that helps protect against damage but gets weaker as we get older.
- The researchers discovered how certain special activators can boost this cleanup crew and even created new versions that can be taken as medicine and reach the brain.
- They found that these activators help improve eye health in mice with a disease that makes them lose their vision, showing that this could be a promising way to treat similar problems in humans.