Publications by authors named "F Monma"
Introduction: Cardiac autonomic system functioning may be altered by obesity leading to cardiovascular diseases and associated complications. Military police officers are exposed to traditional and occupational risk factors for the development of CVD, however data on the cardiovascular health in this population is still scarce.
Aim: In this cross-sectional study, we investigated the impact of obesity on cardiac autonomic modulation and the hemodynamic profile in male active-duty military police officers.
This report addresses whether small molecules can deplete FoxP3-expressing regulatory T (T reg) cells, thereby augmenting antitumor immunity. Imatinib, a tyrosine kinase inhibitor of oncogenic BCR-ABL protein expressed by chronic myelogenous leukemia (CML) cells, possesses off-targets including LCK expressed in T cells. We showed that imatinib-treated CML patients in complete molecular remission (CMR) exhibited selective depletion of effector T reg (eT reg) cells and significant increase in effector/memory CD8+ T cells while non-CMR patients did not.
View Article and Find Full Text PDFBackground: Tyrosine kinase inhibitors markedly improve the survival for patients with chronic myeloid leukemia (CML). However, a decrease in adherence leads to undesired therapeutic outcomes. In this study, the relationships among adherence, pharmacokinetics, response, and adverse effects for dasatinib treatment were prospectively investigated.
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- The JALSG Ph+ALL202 study showed a high complete remission (CR) rate (97%) in patients with Philadelphia chromosome-positive acute lymphoblastic leukemia (Ph+ALL) treated with imatinib and chemotherapy, although the long-term efficacy is still unclear.
- After a median follow-up of 4.5 years, the study found 5-year overall survival and disease-free survival rates were significantly better (50% and 43%, respectively) compared to the pre-imatinib era (15% and 19%).
- Key factors like imatinib treatment, undergoing allogeneic hematopoietic stem cell transplantation (allo-HSCT) in first CR, and a lower white blood cell count improved long
Chronic myeloid leukemia (CML) typically causes leukocytosis rather than thrombocytosis. We encountered two women in their thirties with remarkable thrombocytosis, whose platelet counts were over 3,000×10/µl, and without significant leukocytosis. Although their clinical findings resembled that of essential thrombocythemia (ET), they were diagnosed with CML because of the presence of Philadelphia chromosome.
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