The relationships of plasma profenofos and ethanol concentrations to clinical outcome in acute profenofos self-poisoning.

Introduction: Many patients acutely self-poisoned with organophosphorus insecticides have co-ingested ethanol. Currently, profenofos 50% emulsifiable concentrate (EC50) is commonly ingested for self-harm in Sri Lanka. Clinical experience suggests that ethanol co-ingestion makes management more difficult.

Preclinical evaluation of the efficacy and safety of AAV8-TNAP-D10 in Alpl-/- and AlplPrx1/Prx1 mouse models for the treatment of early and late-onset hypophosphatasia.

We previously documented successful resolution of skeletal and dental disease in the infantile and late-onset murine models of hypophosphatasia (HPP), with a single injection of an adeno-associated serotype 8 vector encoding mineral-targeted TNAP (AAV8-TNAP-D10). Here, we conducted dosing studies in both HPP mouse models. A single escalating dose from 4x108 up to 4x1010 (vg/b) was intramuscularly injected into 4-day-old Alpl-/- mice (an infantile HPP model) and a single dose from 4x106 up to 4x109 (vg/b) was administered to 8-week-old AlplPrx1/Prx1 mice (a late-onset HPP model).

Fully digital workflow for a CAD-CAM custom healing abutment with an optimal emergence profile: A dental technique.

The preoperative fabrication of well-contoured, computer-aided design and computer-aided manufacturing (CAD-CAM), custom healing abutments is essential for guiding soft tissue healing and saving chairside time. This dental technique involves a fully digital workflow to fabricate a CAD-CAM custom healing abutment that relies on preoperative digital implant planning. The healing abutment is designed with an optimal emergence profile that can predictably direct the anatomy of the peri-implant mucosa.

Variations in Cycling Distances by Trip Purpose and Socio-Demographic Attributes: Implications for Spatial Scales to Assess Environmental Correlates of Cycling.

To better understand environmental attributes associated with cycling, it is necessary to identify an area within which such attributes are measured. Various sizes of a "buffer" drawn from home have been used for this purpose. The distances adults cycle to/from their homes may inform the determination of empirically supported buffer sizes.