Publications by authors named "F Mizobe"
Article Synopsis
- The study investigates osilodrostat, a drug for Cushing's disease, and its potential misuse in horse racing due to its anabolic properties, leading to its classification as a banned substance.
- Four thoroughbred horses were given osilodrostat, and extensive screening identified 37 metabolites, with key findings including M1c (a mono-hydroxylated form) and osilodrostat glucuronide, which showed a long detection time in urine.
- For effective doping control, both osilodrostat and M1c should be screened in horse urine samples, and only osilodrostat can be confirmed using a reference material.
Article Synopsis
- Osilodrostat, an anabolic agent developed for Cushing's disease, is banned in horses by major equestrian authorities due to its potential misuse in doping.
- Studies established the elimination profiles of osilodrostat and its metabolite M1c in horse urine, using a validated method for accurate detection post-administration.
- Findings indicate hydrolyzed osilodrostat can be detected for up to 72 hours, while both it and M1c can be found in urine samples for up to 2 weeks, leading to recommendations for monitoring both substances for effective doping control.
Article Synopsis
- Osilodrostat is an inhibitor used to treat Cushing's disease and is banned in horseracing due to its anabolic properties; this study marks the first metabolic analysis of osilodrostat in horses.
- The researchers identified osilodrostat's potential metabolites using advanced mass spectrometry techniques on plasma samples collected before and after drug administration.
- Results showed that the mono-hydroxylated form of osilodrostat was the main metabolite found in plasma, and both the drug and its metabolite remained detectable for up to two weeks, suggesting the need for thorough doping tests in equine sports.
Jockey safety is an important subject from a welfare perspective and public perception. This is the first retrospective case-control study that aims to identify risk factors associated with jockey falls (JF) in Thoroughbred jump races held by the Japan Racing Association (JRA). JF in 17,459 maiden-class race starts at eight racecourses from 2003 to 2017 were retrospectively reviewed.
View Article and Find Full Text PDFJockey safety is of paramount importance from welfare perspective and public perception. This retrospective case-control study aims to identify risk factors associated with jockey falls (JF) in flat races of Japan Racing Association (JRA). JF in 715,210 race starts by 74,328 horses at 10 racecourses from 2003 to 2017 were reviewed.
View Article and Find Full Text PDF