Publications by authors named "F Menozzi Tucci"
Structures of methane and ammonia monooxygenases in native membranes.
Proc Natl Acad Sci U S A
January 2025
Methane- and ammonia-oxidizing bacteria play key roles in the global carbon and nitrogen cycles, respectively. These bacteria use homologous copper membrane monooxygenases to accomplish the defining chemical transformations of their metabolisms: the oxidations of methane to methanol by particulate methane monooxygenase (pMMO) and ammonia to hydroxylamine by ammonia monooxygenase (AMO), enzymes of prime interest for applications in mitigating climate change. However, investigations of these enzymes have been hindered by the need for disruptive detergent solubilization prior to structure determination, confounding studies of pMMO and precluding studies of AMO.
View Article and Find Full Text PDFAdvances in bladder cancer (BCa) treatment have been hampered by the lack of predictive biomarkers and targeted therapies. Here, we demonstrate that loss of the tumor suppressor NUMB promotes aggressive bladder tumorigenesis and worsens disease outcomes. Retrospective cohort studies show that NUMB-loss correlates with poor prognosis in post-cystectomy muscle-invasive BCa patients and increased risk of muscle invasion progression in non-muscle invasive BCa patients.
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- Hematopoietic Stem Cell (HSC) gene therapy can potentially provide long-lasting treatment for various genetic blood disorders, but its effects in different patients are not fully understood.
- A study involving 53 patients with conditions like metachromatic leukodystrophy and β-thalassemia showed that the success of HSC gene therapy varies based on disease type, age, and extent of correction.
- The research identified that while half of the treated patients had stem cells with broad lineage potential, the other half showed specific preferences for producing certain types of blood cells based on their underlying conditions, indicating that HSC function adapts to disease circumstances.
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- Pleomorphic liposarcoma (PLPS) is a rare cancer, and this study focused on the surgical outcomes and treatment strategies for patients with non-metastatic PLPS from 2002 to 2019.* -
- The research involved analyzing data from 44 verified cases, finding that 75% of patients survived for at least five years, with larger tumors linked to worse survival outcomes and higher risks of disease-specific death.* -
- The study concluded that aggressive surgery combined with radiation therapy leads to good local control, while smaller Grade 2 tumors might be effectively treated with surgery alone.*
CoQ (Coenzyme Q) is an essential fat-soluble metabolite that plays a key role in cellular metabolism. A less-known function of CoQ is whether it may act as a plasma membrane-stabilizing agent and whether this property can affect cancer development and progression. Here, we show that CoQ and its biosynthetic enzyme UBIAD1 play a critical role in plasmamembrane mechanical properties that are of interest for breast cancer (BC) progression and treatment.
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