Publications by authors named "F Melfi"
Underrepresentation of women in surgical specialties persists, especially in academic leadership roles. Efforts to better understand disparities and support women cardiothoracic surgeons are ongoing.
View Article and Find Full Text PDFTo investigate DNA methylation levels of a panel of genes in thymic epithelial tumors (TETs). We selected 15 genes among the most promising epigenetic biomarkers of TETs and evaluated their methylation levels in 71 TET samples. thymic carcinomas (TCs) showed hypermethylation of and genes and reduced methylation levels compared with thymomas (TMs) and healthy thymic tissues.
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- Nearly half of the global population is affected by an infection, with current treatments involving antibiotics and proton pump inhibitors; however, rising antimicrobial resistance remains a major issue.
- Phenolic monoterpenes like eugenol, vanillin, carvacrol, and thymol are of interest for their biological activities and potential for easy modifications, leading to the creation of mono- and bis-azo derivatives through aryl diazotization.
- The synthesized compounds were tested against various bacterial strains, revealing some effective inhibitors and subsequently underwent cytotoxicity evaluations and target investigations using structure-based docking calculations on key pharmacological targets.
Ciprofloxacin (CPX) is one of the most employed antibiotics in clinics to date. However, the rise of drug-resistant bacteria is dramatically impairing its efficacy, especially against life-threatening pathogens, such as . This Gram-negative bacterium is an opportunistic pathogen, often infecting immuno-compromised patients with severe or fatal outcomes.
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