Publications by authors named "F McGovern Murphy"
Article Synopsis
- Neuropeptides and neurotrophins are released from dense core vesicles (DCVs), and recent research highlights the unique role of the RAB3-RIM1 pathway in DCV exocytosis, differentiating it from the synaptic vesicle (SV) exocytosis mechanism.
- The study identifies rabphilin-3A (RPH3A) as a negative regulator of DCV exocytosis, where its absence led to a threefold increase in DCV release in RPH3A deficient neurons.
- RPH3A's role in regulating DCV exocytosis is linked to its interaction with SNAP25; although it is not needed for DCV transport, its binding to SNAP25 is
