Publications by authors named "F Mauro"
Background: Rectal cancer (RC) commonly affects older patients. Total Neoadjuvant Therapy (TNT) has been introduced to improve local and systemic control of RC. The aim was to present real-world data of older patients receiving TNT followed by surgery after a frailty assessment and verify feasibility and safety of this approach.
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- - The study aimed to assess how the COVID-19 pandemic affected sperm quality in men, due to the presence of the virus's receptor in the testicles and the increased social isolation during the pandemic.
- - Researchers analyzed 409 semen samples from men over two periods: before the pandemic and after. They found that men who had COVID-19 showed a significant decrease in sperm count, particularly in the acute phase, but levels returned to normal over time.
- - The findings suggest that the reduction in sperm count is likely linked to temporary factors such as fever and inflammation rather than direct effects of the virus or the consequences of social isolation or vaccination.
CD49d expression is included in a revised 4-factor model predicting outcome in patients with chronic lymphocytic leukemia treated with ibrutinib: A multicenter real-world experience.
Hemasphere
July 2024
The new life of ibrutinib therapy in CLL: enhancing personalized approaches.
Expert Rev Anticancer Ther
September 2024
The treatment landscape for CLL has undergone a profound transformation with the advent of targeted agents (TAs) like Bruton's Tyrosine Kinase inhibitors (BTKis) and BCL-2 inhibitors (BCL-2is). These agents target crucial cellular pathways in CLL, offering superior efficacy over traditional chemo-immunotherapy, which has led to improved progression-free and overall survival rates. This advancement promises enhanced disease control and potentially normal life expectancy for many patients.
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