Publications by authors named "F Mauguiere"
Objective: There is currently scarce data on the electroclinical characteristics of epilepsy associated with synapsin 1 (SYN1) pathogenic variations. We examined clinical and electro-encephalographic (EEG) features in patients with epilepsy and SYN1 variants, with the aim of identifying a distinctive electroclinical pattern.
Methods: In this retrospective multicenter study, we collected and reviewed demographic, genetic, and epilepsy data of 19 male patients with SYN1 variants.
Some of the most important integrative control centers for the autonomic nervous system are located in the brainstem and the hypothalamus. However, growing recent neuroimaging evidence support that a set of cortical regions, named the central autonomic network (CAN), is involved in autonomic control and seems to play a major role in continuous autonomic cardiac adjustments to high-level emotional, cognitive or sensorimotor cortical activities. Intracranial explorations during stereo-electroencephalography (SEEG) offer a unique opportunity to address the question of the brain regions involved in heart-brain interaction, by studying: (i) direct cardiac effects produced by the electrical stimulation of specific brain areas; (ii) epileptic seizures inducing cardiac modifications; (iii) cortical regions involved in cardiac interoception and source of cardiac evoked potentials.
View Article and Find Full Text PDFVisceral and emotional responses to direct electrical stimulations of the cortex.
Ann Clin Transl Neurol
January 2023
Objective: Visceral sensations are bodily symptoms which are component manifestations of emotions frequently reported during epileptic seizures. Nowadays, the underlying mechanism and location of brain areas involved in the processing of these sensations remain unclear. Our objectives were to characterize the type and frequency of visceral and emotional responses evoked by electrical stimulations, to produce a mapping of brain structures involved in their processing, and to assess the link between visceral sensations and emotional feelings.
View Article and Find Full Text PDFArticle Synopsis
- Neurodevelopmental disorder with spastic diplegia and visual defect (NEDSDV) is a rare syndrome linked to genetic variations, characterized by developmental delays, intellectual issues, and visual problems, but has not been commonly associated with exaggerated startle responses until now.
- A study involving 12 NEDSDV patients revealed that all exhibited exaggerated startle reactions, which caused falls and injuries in some cases, with findings suggesting this could be a form of atypical hyperekplexia.
- The research emphasizes the need for healthcare providers to routinely ask about startle responses in NEDSDV patients, as these reactions can lead to serious consequences but can be managed with appropriate treatment.*
Article Synopsis
- The insula has two parts: the posterior insula (PI) helps with sensing and movement, while the anterior insula (AI) deals with emotions and is connected to other brain areas.
- In a study, scientists looked at how these two parts reacted to different emotional faces, like pain and fear, while the person's attention was distracted.
- The PI responded to all types of faces, even neutral ones, but the AI only reacted to emotional faces, especially ones showing pain and fear, suggesting that the AI quickly picks up important emotional signals before we fully understand them.