Publications by authors named "F Mashayekhi"
Background: An increasing number of studies have demonstrated that excessive proliferation and apoptosis play a pivotal role in the development of endometriosis.
Aim: The aim of the study was to evaluate the expression of long non-coding RNA (lncRNA) FAS-AS1, FAS, soluble Fas (sFas) and caspase-3 in patients with different stages of endometriosis.
Setting And Design: The design of the study was a cross-sectional study.
Uncontrolled degradation and collapse of stalled replication forks (RFs) are primary sources of genomic instability, yet the molecular mechanisms for protecting forks from degradation/collapse remain to be fully elaborated. Here, we show that polynucleotide kinase-phosphatase (PNKP) localizes at stalled forks and protects stalled forks from excessive degradation. The loss of PNKP results in nucleolytic degradation of nascent DNA at stalled RFs.
View Article and Find Full Text PDFRetraction of "3D Printing of Alginate/Chitosan-Based Scaffold Empowered by Tyrosol-Loaded Niosome for Wound Healing Applications: In Vitro and In Vivo Performances".
ACS Appl Bio Mater
December 2024
Background: The current advances in radiotherapy (RT) have improved the outcome of breast cancer (BC) patients. Despite its therapeutic benefits, the iatrogenic toxicities of RT and its impact on BC survivors are still debated, and further evaluations should be considered. This study aims to assess the rate of subclinical hypothyroidism and hypoparathyroidism among BC patients who were exposed to therapeutic radiation.
View Article and Find Full Text PDFArticle Synopsis
- Okazaki fragment maturation (OFM) is essential for maintaining genome integrity, and its disruption can lead to DNA damage associated with diseases like cancer and neurodegeneration.
- Recent research has identified the role of polynucleotide kinase-phosphatase (PNKP) alongside LIG3-XRCC1 in an alternative pathway for OFM, demonstrating its significance in DNA replication.
- PNKP is shown to be involved in replication fork dynamics and is phosphorylated by cyclin-dependent kinases (CDK1/2), which is crucial for its function in DNA replication and maintaining genome stability.