Publications by authors named "F Martinelli Boneschi"

Introduction: The influence of COVID19 vaccination on the risk of different neurological diseases has been subject of intense investigation. No large scale results have been published so far in the population of around 10 million people of Lombardia in Italy.

Methods: Linkable administrative health databases from the Lombardia region were used.

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Background: Inter-individual differences in treatment response are marked in multiple sclerosis (MS). This is true for Natalizumab (NTZ), to which a subset of patients displays sub-optimal treatment response. We conducted a multi-centric genome-wide association study (GWAS), with additional pathway and network analysis to identify genetic predictors of response to NTZ.

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The emergence of COVID-19 was rapidly followed by infection and the deaths of millions of people across the globe. With much of the research and scientific advancement rightly focused on reducing the burden of severe and critical acute COVID-19 infection, the long-term effects endured by those who survived the acute infection has been previously overlooked. Now, an appreciation for the post-COVID-19 condition, including its neurological manifestations, is growing, although there remain many unknowns regarding the etiology and risk factors of the condition, as well as how to effectively diagnose and treat it.

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Article Synopsis
  • - The study aimed to investigate the effects of long-term exposure to air pollutants (PM2.5, PM10, and NO2) on the severity of Covid-19 pneumonia specifically in patients with Multiple Sclerosis (MS), building on previous research that only considered PM2.5.
  • - Researchers conducted a case-control study with 491 MS patients, utilizing statistical methods such as logistic regression and weighted quantile sum regression to analyze the relationship between pollutant exposure and the likelihood of developing Covid-19 pneumonia.
  • - Results indicated that higher levels of PM2.5, PM10, and NO2 were significantly linked to increased chances of Covid-19 pneumonia, with NO2 and PM2.5 identified as the most
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Article Synopsis
  • - COVID-19 has led to over 3.5 million deaths and more than 160 million infections, with many individuals experiencing neurological issues, including loss of smell, seizures, and strokes, which can lead to long-term cognitive and neuropsychiatric problems regardless of the severity of respiratory symptoms.
  • - The article explores potential links between COVID-19 and neurological symptoms, particularly focusing on Alzheimer's disease and related dementias, while examining factors like inflammation and viral mechanisms that may cause such issues.
  • - A global research effort, the CNS SC2 consortium, is underway to standardize methods for studying the long-term effects of COVID-19 on brain health, with data collection occurring across multiple countries to improve overall understanding.
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