Publications by authors named "F Marques Molias"
Circular RNAs (circRNAs) are produced by head-to-tail back-splicing which is mainly facilitated by base-pairing of reverse complementary matches (RCMs) in circRNA flanking introns. Adenosine deaminases acting on RNA (ADARs) are known to bind double-stranded RNAs for adenosine to inosine (A-to-I) RNA editing. Here we characterize ADARs as potent regulators of circular transcriptome by identifying over a thousand of circRNAs regulated by ADARs in a bidirectional manner through and beyond their editing function.
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- RNA editing can alter RNA sequences and is linked to cancer, particularly a type called hepatocellular carcinoma (HCC), where the COPA protein plays a significant role.
- * In a study with 125 HCC patients, researchers used CRISPR to examine how changes in COPA's RNA sequence affect its function and stability, showing that edited COPA can shift from promoting tumors to suppressing them.
- * The findings suggest that decreased RNA editing of COPA leads to tumor growth by destabilizing the protein and activating cancer-promoting pathways, highlighting the importance of RNA editing in cancer development.
RNA editing introduces nucleotide changes in RNA sequences. Recent studies have reported that aberrant A-to-I RNA editing profiles are implicated in cancers. Albeit changes in expression and activity of genes are thought to have been responsible for the dysregulated RNA editome in diseases, they are not always correlated, indicating the involvement of secondary regulators.
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