Ependymal invasion in High-Grade Glioma. Impact on surgical, functional outcomes, and survival rates. Experience in a Latin-American center.

Objective: Analyze the impact of ependymal invasion in high-grade gliomas (HGG) on surgical, functional outcomes, and survival rates.

Materials And Methods: Retrospective, single-center, analytical study of a cohort of adult patients who underwent surgery for HGG at an Argentine center between 2013 and 2023. Patients with Grade IV supratentorial gliomas, with at least 3 months of follow-up and pre-/postoperative volumetric MRI were evaluated for the presence of ependymal invasion and its impact on prognosis.

Ventricular opening in High-Grade Glioma surgery. Impact on surgical, functional outcomes, and survival rates. Experience in a Latin-American center.

Objective: Analyze the impact of ventricular opening during surgery for High-Grade Glioma (HGG) on surgical, functional outcomes, and survival rates.

Materials And Methods: Retrospective, single-center, analytical study of a cohort of patients who underwent surgery for HGG in an Argentine center between 2013 and 2023. Patients with Grade IV supratentorial gliomas, 3 months of minimum follow-up, studied with pre and postoperative volumetric MRI were included.

Antibacterial and antibiofilm properties of two cyclic dipeptides produced by a new desert Streptomyces sp. HG-17 strain against multidrug-resistant pathogenic bacteria.

Introduction: The emergence of multidrug-resistant bacteria and biofilms requires discovering new antimicrobial agents from unexplored environments.

Objectives: This study aims to isolate and characterize a new actinobacterial strain from the Hoggar Mountains in southern Algeria and evaluate its ability to produce bioactive molecules with potential antibacterial and antibiofilm activities.

Methods: A novel halotolerant actinobacterial strain, designated HG-17, was isolated from the Hoggar Mountains, and identified based on phenotypic characterizations, 16S rDNA sequence analysis, and phylogenetic analysis.

Cytidine Deaminase Resolves Replicative Stress and Protects Pancreatic Cancer from DNA-Targeting Drugs.

Unlabelled: Cytidine deaminase (CDA) functions in the pyrimidine salvage pathway for DNA and RNA syntheses and has been shown to protect cancer cells from deoxycytidine-based chemotherapies. In this study, we observed that CDA was overexpressed in pancreatic adenocarcinoma from patients at baseline and was essential for experimental tumor growth. Mechanistic investigations revealed that CDA localized to replication forks where it increased replication speed, improved replication fork restart efficiency, reduced endogenous replication stress, minimized DNA breaks, and regulated genetic stability during DNA replication.