Publications by authors named "F Mahuteau-Betzer"
Article Synopsis
- Proteins are essential for understanding diseases, making them key targets for diagnostic sensors that can detect changes in biological samples.
- A new fluorescence-based sensing array utilizes a specific chemical interaction to identify and analyze 14 different proteins with over 98% accuracy.
- This sensor is optimized for efficiency using a microfluidic platform, allowing for high-throughput testing and potential use in diagnosing various diseases.
Article Synopsis
- The human immune system continues to develop for several years after birth, affecting how young children respond to infections, such as SARS-CoV-2.
- Researchers studied T cell responses in children and adults before, during, and after SARS-CoV-2 infection, revealing that younger children (under 5) had a weaker CD4 T cell response compared to older children and adults with mild disease.
- Following infection, preschool-age children produced similar neutralizing antibodies to adults but had different T cell characteristics and fewer memory B cells, indicating a gradual maturation of their adaptive immune responses.
In this paper, we demonstrate the existence of an endogenous mitochondrial azoreductase (AzoR) activity that can induce the cleavage of N═N double bonds of azobenzene compounds under normoxic conditions. To this end, 100% OFF-ON azo-based fluorogenic probes derived from 4-amino-1,8-naphthalimide fluorophores were synthesized and evaluated. The in vitro study conducted with other endogenous reducing agents of the cell, including reductases, demonstrated both the efficacy and the selectivity of the probe for AzoR.
View Article and Find Full Text PDFFluorogenic bioorthogonal reactions are promising tools for tracking small molecules or biomolecules in living organisms. Two-photon excitation, by shifting absorption towards the red, significantly increases the signal-to-noise ratio and decreases photodamage, while allowing imaging about 10 times deeper than with a confocal microscope. However, efficient two-photon excitable fluorogenic probes are currently lacking.
View Article and Find Full Text PDFThis symposium is the third PSL (Paris Sciences & Lettres) Chemical Biology meeting (2016, 2019, 2023) held at Institut Curie. This initiative originally started at Institut de Chimie des Substances Naturelles (ICSN) in Gif-sur-Yvette (2013, 2014), under the directorship of Professor Max Malacria, with a strong focus on chemistry. It was then continued at the Institut Curie (2015) covering a larger scope, before becoming the official PSL Chemical Biology meeting.
View Article and Find Full Text PDF