Publications by authors named "F Macchiarini"
Article Synopsis
- - Canagliflozin (Cana) increases lifespan by 14% in male mice but doesn’t affect female mice, according to a study involving 7-month-old genetically diverse male mice.
- - A histopathological analysis of 22-month-old mice showed that Cana reduced the severity of various age-related diseases in male mice, including heart disease, kidney issues, and certain tumors, but also provided protection against pancreas atrophy in both sexes.
- - The findings suggest that Canagliflozin may slow down the aging process and could have potential benefits for other health issues associated with aging, warranting further research.
Article Synopsis
- Mice genetically heterogeneous from a specific cross showed a significant increase in male lifespan by 19% when fed a non-feminizing estrogen, 17-α-estradiol (17aE2), starting at 16 months and by 11% starting at 20 months.
- Other treatments tested, including nicotinamide riboside and three others, did not show substantial lifespan benefits for the mice.
- The study reinforces earlier findings about 17aE2, suggesting that it may offer important insights into sex-specific aging processes since it provided notable lifespan extensions even when dosing began later in life.
To see if variations in timing of rapamycin (Rapa), administered to middle aged mice starting at 20 months, would lead to different survival outcomes, we compared three dosing regimens. Initiation of Rapa at 42 ppm increased survival significantly in both male and female mice. Exposure to Rapa for a 3-month period led to significant longevity benefit in males only.
View Article and Find Full Text PDFCanagliflozin (Cana) is an FDA-approved diabetes drug that protects against cardiovascular and kidney diseases. It also inhibits the sodium glucose transporter 2 by blocking renal reuptake and intestinal absorption of glucose. In the context of the mouse Interventions Testing Program, genetically heterogeneous mice were given chow containing Cana at 180 ppm at 7 months of age until their death.
View Article and Find Full Text PDFDiets low in methionine extend lifespan of rodents, though through unknown mechanisms. Glycine can mitigate methionine toxicity, and a small prior study has suggested that supplemental glycine could extend lifespan of Fischer 344 rats. We therefore evaluated the effects of an 8% glycine diet on lifespan and pathology of genetically heterogeneous mice in the context of the Interventions Testing Program.
View Article and Find Full Text PDF