Publications by authors named "F MOREAU"
Article Synopsis
- Non-stenotic carotid plaques, identified as having less than 50% stenosis, are considered a potential factor in ischemic strokes, particularly in patients with low-risk neurological events.
- The study analyzed data from 334 patients who experienced minor neurological symptoms and underwent CT angiography and MRI, finding that nearly 46% had these non-stenotic plaques, with a notable prevalence among those showing DWI-positive ischemia.
- The results indicated that non-stenotic plaques are more common on the side of DWI-positive lesions, suggesting a significant association between these plaques and the risk of ischemic events, as patients with non-stenotic plaques had a 40% higher risk for DWI-positive ischemia.
Background And Purpose: Sonothrombolysis is a potential adjunctive therapy for large vessel occlusion (LVO) stroke. Bedside ultrasound image-guided high-intensity focused ultrasound (HIFU) therapy could deliver higher energy therapeutic ultrasound to the thrombus with higher precision than what was previously accomplished in human trials. The aim is to test the feasibility of diagnostic transcranial contrast-enhanced ultrasound (CEUS) to image the occlusion site and continuously maintain the guidance image on-target for a sufficient exposure time for HIFU to be effective during LVO stroke evaluation and treatment.
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- The formation of a lytic immunological synapse (IS) is essential for cytotoxic lymphocytes to effectively target and destroy cancer cells, but the cancer cell side of the IS is less understood.
- Recent research shows that cancer cells can quickly rearrange their actin cytoskeleton towards the IS when interacting with natural killer (NK) cells, helping them evade destruction.
- Preliminary findings indicate that this actin remodeling is linked to the secretion of small extracellular vesicles, which may assist cancer cells in avoiding immune attacks, highlighting the need for more research on this immune evasion mechanism.
Astronomical precision spectroscopy underpins searches for life beyond Earth, direct observation of the expanding Universe and constraining the potential variability of physical constants on cosmological scales. Laser frequency combs can provide the required accurate and precise calibration to the astronomical spectrographs. For cosmological studies, extending the calibration with such astrocombs to the ultraviolet spectral range is desirable, however, strong material dispersion and large spectral separation from the established infrared laser oscillators have made this challenging.
View Article and Find Full Text PDFObjectives: Several drug-drug interaction (DDI) checkers such as DDI-Predictor have been developed to detect and grade DDIs. DDI-Predictor gives an estimate of the magnitude of an interaction based on the ratio of areas under the curve. The objective of the present study was to analyse the frequencies of DDIs involving well-known strong interactors such as rifampicin and selective serotonin reuptake inhibitors (SSRIs), as reported by a clinical pharmacy team using DDI-Predictor, and the pharmacist intervention acceptance rate.
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