Publications by authors named "F M Y Lim"
Phagocytic clearance of apoptotic cancer cells (efferocytosis) by tumor-associated macrophages (TAMs) contributes in a substantial manner to the establishment of an immunosuppressive tumor microenvironment. This puts in context our observation that the female steroid hormone 17β-estradiol (E2) facilitates tumor immune resistance through cancer cell extrinsic Estrogen Receptor (ERalpha;) signaling in TAMs. Notable was the finding that E2 induces the expression of CX3CR1 in TAMs to enable efferocytosis of apoptotic cancer cells which results in the suppression of type I interferon (IFN) signaling.
View Article and Find Full Text PDFOutcome of extra-nodal follicular lymphoma affected by choice of induction chemoimmunotherapy and maintenance rituximab - real-world retrospective study.
Leuk Lymphoma
December 2024
The importance of extra-nodal disease has been well recognized in follicular lymphoma, and is incorporated into various prognostic tools. However, the optimal treatment strategy for this subgroup remains unclear. In this multicenter retrospective study, we analyzed 143 patients who received either R-CHOP or Bendamustine-Rituximab (BR), with a median follow-up of 69.
View Article and Find Full Text PDFImpact of C-MYC/BCL2 Double Expression on Survival Outcomes After Autologous Transplantation in Relapsed/Refractory Diffuse Large B Cell Lymphoma-A Nationwide Retrospective Analysis in Singapore.
Hematol Oncol
January 2025
Background: An estimated 44.1 million US citizens are living with disabilities. People with disabilities are at higher risk for health problems, affecting their overall quality of life and care experience.
View Article and Find Full Text PDFArticle Synopsis
- Polymyositis is a rare complication of graft-versus-host disease (GvHD) that primarily affects muscle tissues, particularly in patients after stem cell transplants.
- A 23-year-old male with chronic myeloid leukemia experienced severe muscle weakness and respiratory issues six months post-transplant, leading to the diagnosis of GvHD polymyositis through various tests including muscle biopsies and imaging.
- The patient responded positively to treatments like corticosteroids and extracorporeal photopheresis, underscoring the need for prompt diagnosis and a collaborative approach to managing this condition.