Publications by authors named "F M Watt"
Caspase-8-dependent autophagy regulates neutrophil infiltration in oral squamous cell carcinoma.
Proc Natl Acad Sci U S A
December 2024
Oral squamous cell carcinoma (OSCC) is a subtype of head and neck cancer that arises in the multilayered epithelia of the mouth and lips. Although inactivating mutations in are frequently found in human OSCC their role in the disease is unknown. To investigate this, we deleted in the oral epithelium of adult mice.
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- Ultrasound imaging often uses a fast delay-and-sum algorithm, but this can cause image issues with low channel count systems.
- Model-based inversion methods can reduce these artefacts but usually require high computational resources, making real-time use challenging.
- The presented direct model-based inversion (DMI) method for optical ultrasound (OpUS) showed significant improvements in image quality and speed, making it viable for other low channel-count imaging systems as well.
Objectives: To develop a protocol for largescale analysis of synovial fluid proteins, for the identification of biological networks associated with subtypes of osteoarthritis.
Methods: Synovial Fluid To detect molecular Endotypes by Unbiased Proteomics in Osteoarthritis (STEpUP OA) is an international consortium utilising clinical data (capturing pain, radiographic severity and demographic features) and knee synovial fluid from 17 participating cohorts. 1746 samples from 1650 individuals comprising OA, joint injury, healthy and inflammatory arthritis controls, divided into discovery (n = 1045) and replication (n = 701) datasets, were analysed by SomaScan Discovery Plex V4.
Aims: To explore key stakeholder views around feasibility and acceptability of trials seeking to prevent post-traumatic osteoarthritis (PTOA) following knee injury, and provide guidance for next steps in PTOA trial design.
Methods: Healthcare professionals, clinicians, and/or researchers (HCP/Rs) were surveyed, and the data were presented at a congress workshop. A second and related survey was then developed for people with joint damage caused by knee injury and/or osteoarthritis (PJDs), who were approached by a UK Charity newsletter or Oxford involvement registry.