[Microbial intestinal disturbances in children with frequent acute complicated pneumonia].

In the investigation designed to study intestinal microflora in children with acute complicated pneumonia having developed against the background of frequently recurring diseases such as acute respiratory infections, 91.1 percent of pediatric examinees demonstrated microecologocal disturbances in the intestines, with grade III dysbacteriosis in 46.6 percent.

[Microbiocenosis of the large intestine in acute complicated pneumonia in children].

Fifty-six children of early age with pneumonia developed on the background of frequent respiratory infections were placed under observation. In 91.1% of these cases microecological disturbances in the intestine were detected, 46.

[Clinico-pathogenetic aspects of infectious toxicosis in infants caused by acute pneumonia].

Altogether 101 children under one year of age with infectious toxicosis due to acute pneumonia were examined for the clinical, roentgenomorphological and biochemical aspects of the given condition. The clinical aspects were delineated on the basis of the universal status covered by the formalized case report. The biochemical processes were analyzed according to the content of peroxidation products of membrane lipids, the concentration of hydrogen peroxide, phospholipase activity, antioxidant and antiperoxide defence of the blood as well as according to the physical constants of red blood cell membranes.

[Antioxidation and membrane-stabilizing therapy of hypoxic conditions in newborn infants].

It has been found that a most important mechanism underlying the development of various pathological conditions in the organism of neonates with perinatal hypoxic lesions of the central nervous system is the structural and functional disorganization of the cell membranes. This is associated with activation of lipid peroxidation, effect of lysosomal enzymes, and impairment of antioxidative defense. As a result, the membrane content of most important lipids is changed, their degenerative forms appear, lipoperoxides accumulate, and the activity of the membrane enzymes is inhibited.

[Clinical value of studying phospholipids in young children with acute pneumonia].

A study was made of phospholipid metabolism in 268 children aged 1 month to 3 years, who were in a critical condition consequent on acute complicated pneumonia. Unbalance of that type metabolism was revealed. It consisted in intensive accumulation of lysophosphatidylcholine, sphingomyelin in the stroma of red blood cells and in a decrease of their pool in the blood plasma as well as in a reduction of the content of phosphatidylserine and phosphatidylethanolamine towards the plasma pool.