Publications by authors named "F M Randall"
Alzheimer's disease dementia (ADD) is the most diffuse neurodegenerative disorder belonging to mild cognitive impairment (MCI) and dementia in old persons. This disease is provoked by an abnormal accumulation of amyloid-beta and tauopathy proteins in the brain. Very recently, the first disease-modifying drug has been licensed with reserve (i.
View Article and Find Full Text PDFArticle Synopsis
- Researchers recommend using cerebrospinal and neuroimaging biomarkers for diagnosing Alzheimer's disease (AD) and other dementias, yet these methods don't clarify how AD affects cognitive processes.
- An Expert Panel found consistent abnormalities in event-related electroencephalographic oscillations (EROs) among AD patients and those with related conditions, showing reduced delta and theta activity linked to cognitive deficits.
- While delta and theta EROs may serve as useful biomarkers in clinical trials for AD, there's still a lack of research on their relevance in other dementias, indicating a need for further investigation.
Abnormal excitability in cortical networks has been reported in patients and animal models of Alzheimer's disease (AD), and other neurodegenerative conditions. Whether hyperexcitability is a core feature of alpha(α)-synucleinopathies, including dementia with Lewy bodies (DLB) is unclear. To assess this, we used two murine models of DLB that express either human mutant α-synuclein (α-syn) the hA30P, or human wild-type α-syn (hWT-α-syn) mice.
View Article and Find Full Text PDFIntroduction: Children are increasingly diagnosed with mental illnesses and self-harm behaviors. They present frequently to the emergency department (ED) for evaluation. The aim of this study is to describe the youngest children in the ED with psychiatric issues.
View Article and Find Full Text PDF