Reinforcement Learning Optimization of the Charging of a Dicke Quantum Battery.

Quantum batteries are energy-storing devices, governed by quantum mechanics, that promise high charging performance thanks to collective effects. Because of its experimental feasibility, the Dicke battery-which comprises N two-level systems coupled to a common photon mode-is one of the most promising designs for quantum batteries. However, the chaotic nature of the model severely hinders the extractable energy (ergotropy).

Unveiling adipose populations linked to metabolic health in obesity.

Precision medicine is still not considered as a standard of care in obesity treatment, despite a large heterogeneity in the metabolic phenotype of individuals with obesity. One of the strongest factors influencing the variability in metabolic disease risk is adipose tissue (AT) dysfunction; however, there is little understanding of the link between distinct cell populations, cell-type-specific transcriptional programs, and disease severity. Here, we generated a comprehensive cellular map of subcutaneous and visceral AT of individuals with metabolically healthy and unhealthy obesity.

Sustained intermittent and continuous isometric muscle actions induce different levels of fatigue for the same force-time integral.

Introduction: The aim was to compare the fatiguing effects induced by continuous (CONT) and intermittent (INT) tasks of an identical duration by equating the force-time integral.

Method: ː Fourteen men performed two sequences (4 blocks of 378s) of contractions (CONT or INT) of the quadriceps femoris. The CONT contraction of 378s corresponded to 10% of the maximum voluntary muscle contraction (MVC).

Thyroid hormones are required for thermogenesis of beige adipocytes induced by Zfp423 inactivation.

The significance of thyroid hormones (THs) in beige adipocyte thermogenesis remains incompletely understood. We previously reported that THs directly regulate the expression of zinc-finger protein 423 (ZFP423), an anti-thermogenic factor, in adipose tissue. This study investigates the interaction between THs and adrenergic signaling in regulating thermogenic capacity and activation of beige adipocytes formed in response to Zfp423 deletion.

Adipose tissue retains an epigenetic memory of obesity after weight loss.

Reducing body weight to improve metabolic health and related comorbidities is a primary goal in treating obesity. However, maintaining weight loss is a considerable challenge, especially as the body seems to retain an obesogenic memory that defends against body weight changes. Overcoming this barrier for long-term treatment success is difficult because the molecular mechanisms underpinning this phenomenon remain largely unknown.