Publications by authors named "F M Mulcahy"
Article Synopsis
- The study introduces a new method for verifying the accuracy of electrode placement during robotic-assisted stereotactic electroencephalography (sEEG) surgery, focusing on its importance in reducing complications and enhancing efficacy.* -
- A retrospective review of 111 sEEG surgeries found that the registration checkpoint identified intraoperative errors in 4 cases, allowing for corrections before finishing the procedure.* -
- Implementing a registration checkpoint in sEEG surgery is straightforward and can significantly enhance patient safety by preventing potential electrode misplacements.*
Sequencing of most genomes excludes repeat regions in and the gene, encoding the acidic repeat protein (). As a first step to understanding the evolution and function of these genes and the proteins they encode, we developed a protocol to nanopore sequence and genes from 212 clinical samples collected from ten countries on six continents. Both and repeat structures recapitulate the whole genome phylogeny, with subclade-specific patterns emerging.
View Article and Find Full Text PDFIn spite of its immutable susceptibility to penicillin, Treponema pallidum (T. pallidum) subsp. pallidum continues to cause millions of cases of syphilis each year worldwide, resulting in significant morbidity and mortality and underscoring the urgency of developing an effective vaccine to curtail the spread of the infection.
View Article and Find Full Text PDFCD8 encephalitis with CSF EBV viraemia and HIV drug resistance, a case series.
Brain Behav Immun Health
December 2020
Introduction: CD8 encephalitis is a relatively recently described condition in the setting of HIV infection. It is becoming increasingly recognised in recent years though is still likely underdiagnosed.
Methods: We present three cases of encephalitis in HIV-positive black African females initially presenting with neurological pathology.
Background: DNA methylation-based estimators of biological age are reliable biomarkers of the ageing process. We aimed to investigate a range of epigenetic ageing biomarkers in a substudy of the NEAT001/ANRS143 clinical trial, which compared ritonavir-boosted darunavir with either raltegravir or tenofovir disoproxil fumarate and emtricitabine in antiretroviral therapy (ART)-naive adults.
Methods: We analysed frozen whole blood samples from 168 ART-naive participants with HIV from the NEAT001/ANRS143 trial, before ART initiation and after 2 years of ART (84 participants on ritonavir-boosted darunavir with raltegravir and 84 participants on ritonavir-boosted darunavir with tenofovir disoproxil fumarate and emtricitabine).