Publications by authors named "F M Mertens"
Calciprotein particles (CPPs) are an endogenous buffering system, clearing excessive amounts of Ca and PO from the circulation and thereby preventing ectopic mineralization. CPPs circulate as primary CPPs (CPP1), which are small spherical colloidal particles, and can aggregate to form large, crystalline, secondary CPPs (CPP2). Even though it has been reported that CPPs are toxic to vascular smooth muscle cells (VSMC) in vitro, their effect(s) on the vasculature remain unclear.
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- Myxofibrosarcoma (MFS) and undifferentiated pleomorphic sarcoma (UPS) are aggressive types of soft tissue sarcoma, and this study aimed to explore their differences in gene expression and how these relate to clinical outcomes.
- A total of 162 patients were analyzed through RNA-sequencing, comparing gene profiles with clinical data and genomic features to reveal significant overlap between MFS and UPS while identifying distinct transcriptomic clusters.
- The findings suggest that although MFS and UPS have similar genetic characteristics, UPS tends to be more aggressive, indicating potential for important subgroups that could influence treatment decisions.
Chromosomal aneuploidy, that is, numerical chromosome aberrations, is one of the molecular hallmarks of cancer. However, when neoplasms are studied with sequencing- and array-based approaches, chromosome numbers and ploidy states are typically inferred from bulk DNA data. Furthermore, published molecular estimates of neoplasia-associated aneuploidy often also include genomic imbalances resulting from various types of structural rearrangement, which likely result from other mechanisms than numerical chromosome aberrations.
View Article and Find Full Text PDFNear-haploidization, that is, loss of one copy of most chromosomes, is a relatively rare phenomenon in most tumors, but is enriched among certain soft tissue sarcomas, including undifferentiated pleomorphic sarcoma (UPS). Presumably, near-haploidization can arise through many mechanisms. This study aimed to identify gene rearrangements that could cause near-haploidization.
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- - The study investigates superficial CD34-positive fibroblastic tumors (SCD34FT), a rare low-grade skin neoplasm that often expresses CADM3, in comparison to atypical fibrous histiocytomas (FH).
- - Out of 40 examined cases of atypical FH, 55% of CD34-positive tumors were reclassified as SCD34FT due to their CADM3 positivity and frequent PRDM10 rearrangement.
- - The findings suggest that distinguishing between SCD34FT and atypical FH using CADM3 immunohistochemistry is crucial, as many SCD34FT tumors exhibit morphologic features similar to atypical FH.