Publications by authors named "F M McLellen"
Nicotine is an alkaloid found in tobacco. Human exposure to nicotine primarily occurs through the use of tobacco products. To date, limited nicotine pharmacokinetic data in animals have been reported.
View Article and Find Full Text PDFLorcaserin is a 5-hydroxytryptamine 2C (serotonin) receptor agonist and a nongenotoxic rat carcinogen, which induced mammary tumors in male and female rats in a 2-yr bioassay. Female Sprague Dawley rats were treated by gavage daily with 0, 30, or 100 mg/kg lorcaserin, replicating bioassay dosing but for shorter duration, 12 or 24 wk. To characterize exposure and eliminate possible confounding by a potentially genotoxic degradation product, lorcaserin and N-nitroso-lorcaserin were quantified in dosing solutions, terminal plasma, mammary, and liver samples using ultra-high-performance liquid chromatography-electrospray tandem mass spectrometry.
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- Black cohosh extract is marketed as a dietary supplement to help relieve menopause symptoms and may protect against bone loss in postmenopausal women; however, its interactions with bisphosphonates like risedronate are unclear.
- A study on female rats examined the effects of black cohosh, risedronate, and their combination on bone mineral density over 24 weeks after ovariectomy.
- Results showed that while high doses of risedronate significantly increased bone mineral density, black cohosh extract had no significant effects alone or in combination with risedronate.
We report the data from the guideline-compliant two-year toxicology study conducted as part of the Consortium Linking Academic and Regulatory Insights on Bisphenol A Toxicity (CLARITY-BPA). BPA (0, 2.5, 25, 250, 2,500, and 25,000 μg/kg body weight (bw)/day) was administered daily by gavage in 0.
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