Publications by authors named "F M Koster"
Introduction: PD1/PD-L1 inhibition (ICi) has recently become a new standard of care for patients with advanced MMR-deficient (MMRd) endometrial cancers. Nevertheless, response to immunotherapy is more complex than the presence of a single biomarker and therefore it remains challenging to predict patients response to ICi beyond MMRd tumors. Elevated PD-L1 expression (CPS ≥ 1) is often used as a prognostic marker as well as a predictive biomarker of response to ICi in different tumor types.
View Article and Find Full Text PDFObjectives: Bundled payments (BPs) are increasingly being adopted to enable the delivery of high-value care. For BPs to reach their goals, accounting for differences in patient risk profile (PRP) predictive of spending is crucial. However, insight is lacking into how this is done in practice.
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- Two surveys conducted on displaced workers from five manufacturing plants revealed that two years post-layoff, about 66% had found new jobs, while 20% remained unemployed and 10% had retired.
- After 11 years, overall unemployment among these workers dropped below 5%, suggesting more favorable outcomes compared to other European closures.
- However, older workers, particularly those in their late forties to early fifties, faced significant challenges in finding stable employment and often had to accept lower wages.
Purpose: There are different techniques for ultrasound-guided central venous catheter (CVC) insertion. When using the conventional syringe-on-needle technique, the syringe needs to be removed from the needle after venous puncture to pass the guidewire through the needle into the vein. When, alternatively, using the wire-in-needle technique, the needle is preloaded with the guidewire, and the guidewire-after venous puncture-is advanced into the vein under real-time ultrasound guidance.
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- * The test found HPV L1 high-risk antibodies in nearly all patients with cervical intraepithelial neoplasia (CIN) and cancer while only detecting them in a small percentage of healthy controls.
- * This promising, easy-to-use test could improve early detection of cervical cancer in low- and middle-income countries, where traditional screening methods may not be accessible.