Publications by authors named "F M Hopkins"
Enhancing soil health and nutrient availability for Carrizo citrange (X sp.) through bokashi and biochar amendments: An exploration into indoor sustainable soil ecosystem management.
Sci Hortic
February 2024
Article Synopsis
- * Significant changes in soil properties were noted, with bokashi raising total nitrogen and biochar enhancing total carbon, leading to an optimal 24:1 carbon to nitrogen ratio associated with healthy microbial growth.
- * Both amendments improved germination rates and plant height compared to control soils, demonstrating their effectiveness in enhancing nutrient availability and overall plant development.
Article Synopsis
- Tuberculosis (TB) remains a significant global health issue despite BCG vaccination efforts, warranting research into improved vaccine strategies.
- A study found that administering BCG via intravenous (IV) route instead of intradermal (ID) enhanced protection against TB in a non-human primate model.
- Depletion of specific lymphocyte types, particularly CD4 T cells and innate CD8α+ lymphocytes, compromised this protection, indicating their crucial role in developing more effective TB vaccines.
Concomitant immunity is generally defined as an ongoing infection providing protection against reinfection . Its role in prevention of tuberculosis (TB) caused by (Mtb) is supported by epidemiological evidence in humans as well as experimental evidence in mice and non-human primates (NHPs). Whether the presence of live Mtb, rather than simply persistent antigen, is necessary for concomitant immunity in TB is still unclear.
View Article and Find Full Text PDFConcomitant immunity is generally defined as an ongoing infection providing protection against reinfection. Its role in prevention of tuberculosis (TB) caused by (Mtb) is supported by epidemiological evidence in humans as well as experimental evidence in mice and non-human primates (NHPs). Whether the presence of live Mtb, rather than simply persistent antigen, is necessary for concomitant immunity in TB is still unclear.
View Article and Find Full Text PDFThe functional role of CD8+ lymphocytes in tuberculosis remains poorly understood. We depleted innate and/or adaptive CD8+ lymphocytes in macaques and showed that loss of all CD8α+ cells (using anti-CD8α antibody) significantly impaired early control of Mycobacterium tuberculosis (Mtb) infection, leading to increased granulomas, lung inflammation, and bacterial burden. Analysis of barcoded Mtb from infected macaques demonstrated that depletion of all CD8+ lymphocytes allowed increased establishment of Mtb in lungs and dissemination within lungs and to lymph nodes, while depletion of only adaptive CD8+ T cells (with anti-CD8β antibody) worsened bacterial control in lymph nodes.
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