Auto adaptation of closed-loop insulin delivery system using continuous reward functions and incremental discretization.

Several closed or hybrid loop controllers for Blood Glucose (BG) regulation, which are also known as Artificial Pancreas (AP) Systems or Automated Insulin Delivery systems (AIDs), are in development worldwide. Most AIDs are designed and evaluated for short-term performance, with a particular emphasis on the post-meal period. However, if controllers are not adapted properly to account for variations in physiology that affect Insulin Sensitivity (IS), the AIDs may perform inadequately.

A Dual-Hormone Multicontroller for Artificial Pancreas Systems.

Artificial pancreas (AP) algorithms can be divided into single-hormone (SH) and dual-hormone (DH). SH algorithms regulate glycemia using insulin as their control input. On the other hand, DH algorithms also use glucagon to counteract insulin.

Practical constraint definition in safety schemes for artificial pancreas systems.

Introduction: Artificial pancreas systems usually define an insulin-on-board constraint () for safety schemes to limit the insulin infusion and avoid hypoglycemia during the closed-loop performance. Several methods have been proposed with impractical considerations requiring information from the prandial events or complex procedures for ambulatory use.

Methods: This paper presents a simple method that consists of two novel rules that allow finding an based only on common clinical parameters that do not require patient intervention.

First Outpatient Clinical Trial of a Full Closed-Loop Artificial Pancreas System in South America.

Background: The first two studies of an artificial pancreas (AP) system carried out in Latin America took place in 2016 (phase 1) and 2017 (phase 2). They evaluated a hybrid algorithm from the University of Virginia (UVA) and the automatic regulation of glucose (ARG) algorithm in an inpatient setting using an AP platform developed by the UVA. The ARG algorithm does not require carbohydrate (CHO) counting and does not deliver meal priming insulin boluses.