Publications by authors named "F M C Mello"
Background: Intrahepatic cholangiocarcinoma (iCCA) was considered a contraindication for liver transplantation. However, recent studies have shown that highly selected cases of patients with a good response to neoadjuvant therapy may achieve acceptable survival rates when following liver transplantation.
Aims: To present two cases of patients with iCCA, without extrahepatic disease, who underwent living donor liver transplantation after receiving neoadjuvant chemotherapy.
Background: Despite an existing safe and effective vaccine for hepatitis B virus (HBV), it is still a major public health concern. Nowadays, several drugs are used to treat chronic hepatitis B; however, full healing remains controversial. The viral covalently closed circular DNA (cccDNA) formed by HBV forms a major challenge in its treatment, as does the ability of HBV to integrate itself into the host genome, which enables infection reactivation.
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- The Brazilian Amazon is a key area for hepatitis Delta virus (HDV) with hard-to-reach locations, making it crucial to study how the virus spreads there.
- A molecular analysis of HDV cases, involving 35 patients from Rondônia, Brazil, was conducted using PCR and sequencing to track the virus's evolution and transmission over time.
- Findings indicate that all samples were HDV-3, with an estimated entry into Brazil around 1820, suggesting complex migration patterns throughout the region over the past two centuries.*
In 2022-2023, the first survey of clinicians regarding infection of rabbits was undertaken. The purpose was to assess the current worldwide knowledge of clinicians regarding influence of breed and age, clinical presentations, use of various diagnostic tools, and treatment regimens and to explore how responses may differ by geographic location. Identifying mostly as exotic animal clinicians, 339 respondents participated, with nearly half from the United States and the remainder from 35 other countries.
View Article and Find Full Text PDFIntroduction: For advanced osteoarthritis of the knee and hip, the most clinically effective treatment remains total-knee arthroplasty (TKA) and total-hip arthroplasty (THA). Success of these surgeries have traditionally been appraised by economic and volume-based measures. There has been a shift towards the use of patient reported outcome measures (PROMs) to quantify success and guide treatment.
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