The enhanced weathering potential of a range of silicate and carbonate additions in a UK agricultural soil.

Enhanced weathering (EW) is a carbon dioxide removal (CDR) technology which aims to accelerate silicate and/or carbonate weathering in agricultural land. At present, the rate and magnitude of CDR from EW remains uncertain. In this study, soil cores extracted from a typical UK agricultural site in Oxfordshire were used to geochemically assess the efficacy of EW while simulating field conditions.

Evolution of tropical land temperature across the last glacial termination.

The tropical West Pacific hosts the warmest part of the surface ocean and has a considerable impact on the global climate system. Reconstructions of past temperature in this region can elucidate climate connections between the tropics and poles and the sensitivity of tropical temperature to greenhouse forcing. However, existing data are equivocal and reliable information from terrestrial archives is particularly sparse.

Asymmetric F-fluorination for applications in positron emission tomography.

Positron emission tomography (PET) is becoming more frequently used by medicinal chemists to facilitate the selection of the most promising lead compounds for further evaluation. For PET, this entails the preparation of C- or F-labeled drugs or radioligands. With the importance of chirality and fluorine substitution in drug development, chemists can be faced with the challenge of preparing enantiopure molecules featuring the F-tag on a stereogenic carbon.

Organomediated Enantioselective (18)F Fluorination for PET Applications.

The first organomediated asymmetric (18)F fluorination has been accomplished using a chiral imidazolidinone and [(18)F]N-fluorobenzenesulfonimide. The method provides access to enantioenriched (18)F-labeled α-fluoroaldehydes (>90% ee), which are versatile chiral (18)F synthons for the synthesis of radiotracers. The utility of this process is demonstrated with the synthesis of the PET (positron emission tomography) tracer (2S,4S)-4-[(18)F]fluoroglutamic acid.

Synthetic peptides which inhibit the interaction between C1q and immunoglobulin and prolong xenograft survival.

Background: Acute vascular xenograft rejection (AVXR), also termed delayed xenograft rejection (DXR), occurs when hyperacute rejection (HAR) is prevented by strategies directed at xenoreactive natural antibodies and/or complement activation. We have hypothesized that AVXR/DXR is initiated in part by early components of the complement cascade, notably C1q. We have developed synthetic peptides (termed CBP2 and WY) that interfere with the interaction between C1q and antibody.