Can transcutaneous bilirubinometry safely be used to monitor rebound hyperbilirubinaemia after phototherapy in neonates ≥35 weeks' gestation? A prospective, comparative study.

Introduction: There is insufficient evidence to determine if non-invasive transcutaneous bilirubin (TcB) measurement can replace serum bilirubin (SBR) in assessing rebound hyperbilirubinaemia after phototherapy.

Objective: To investigate if TcB can safely guide management of neonates after phototherapy.

Subjects: 100 well neonates ≥35 weeks' gestation who had received inpatient phototherapy.

Direct injection high performance liquid chromatography coupled to data independent acquisition mass spectrometry for the screening of antibiotics in honey.

The targeted analysis of veterinary drug residues in honey traditionally involves a series of extraction and purification steps prior to quantification with high performance liquid chromatography coupled to high resolution or tandem mass spectrometry. These steps, designed to separate the target analytes from interferences, are generally time-consuming and costly. In addition, traditional cleanup steps are likely to eliminate other compounds whose analysis could prove decisive in current or future assessment of the honey sample.

Peer validation of a method to confirm chloramphenicol in honey by liquid chromatography-tandem mass spectrometry.

Chloramphenicol (CAP) is extracted from an aqueous dilution of honey using ethyl acetate. The extracts are evaporated and redissolved in water. CAP is then extracted from the aqueous solutions using reversed-phase solid-phase extraction cartridges.

Determination of five macrolide antibiotic residues in eggs using liquid chromatography/electrospray ionization tandem mass spectrometry.

A method using liquid chromatography electrospray ionization tandem mass spectrometry (LC/ESI-MS/MS) for the determination of trace levels of five macrolide antibiotics (spiramycin, tilmicosin, oleandomycin, erythromycin, and tylosin) in eggs is presented. Data acquisition under MS/MS was achieved by applying multiple reaction monitoring (MRM) of two or three fragment ion transitions to provide a high degree of sensitivity and specificity for both quantification and confirmation. Matrix-matched standard calibration curves were used to achieve the best accuracy of the method.

The effects of seasonal weather on the genotoxicity, cytokinetic properties, cytotoxicity and organochemical content of extracts of airborne particulates in Mexico City.

Extracted organic material (EOM) from PM10 airborne particles collected during three distinct seasons in Mexico City was assayed for genotoxicity, cytokinetic effects and cytotoxicity. Using sister chromatid exchange (SCE) for genotoxicity, replication index (RI) and mitotic index (MI) for cytokinetics, and microscopic evaluation (cell death) for cytotoxicity on human lymphocytes exposed to increasing concentrations of EOM, this study showed that the extent of genotoxic, cytokinetic, and cytotoxic change caused by pollutants depended at least in part on the seasonal weather. Bioactivated extracts of samplings in April (warm and dry), August (warm and rainy) and November (cool and dry) produced the highest rate of genotoxicity (SCE) in November and the lowest rate in April.