Publications by authors named "F Lunel-Fabiani"
Article Synopsis
- Patients living with HIV in Mauritania are at risk for co-infection with Hepatitis B Virus (HBV) and Hepatitis D Virus (HDV), with a study revealing a 37% prevalence of anti-HDV antibodies among 292 participants.
- The study identified genetic variations in the viruses, showing that HDV genotype 1 was most common, along with HBV genotypes D and E, and noted that significant liver disease progression was observed over an average follow-up of approximately 25 months.
- The findings emphasize the need for screening and treatment strategies for HDV in HIV-positive populations, given the potential for severe liver complications associated with these infections.
Development and field evaluation in African and Asian countries of an hepatitis B virus PCR on open polyvalent platforms to determine treatment eligibility: results from the "Agence Nationale de Recherche sur le Sida et les hépatites" 12327 study.
Clin Microbiol Infect
August 2024
Objectives: Widespread testing and treatment are essential to eliminate hepatitis B virus (HBV) infection as a public health concern. However, in resource-limited countries, access to HBV PCR is limited. In this study, we developed a quantitative HBV PCR assay on open molecular platforms and evaluate its performance in diagnosing clinically significant HBV DNA thresholds as defined by the WHO (2000 IU/mL, 20 000 IU/mL, and 200 000 IU/mL).
View Article and Find Full Text PDFIntroduction: Infection by hepatitis B virus (HBV) is a major issue in public health. The prevalence of HBV in Chad is 12.4%, all age groups considered.
View Article and Find Full Text PDFIn 2022, the World Health Organization (WHO) estimated that hepatitis B virus (HBV) infections caused 1.5 million deaths, mostly attributable to complications from chronic infections, cirrhosis and hepatocellular carcinoma (HCC). Despite the availability of a vaccine, 296 million people were chronically infected in 2019.
View Article and Find Full Text PDFThe A1762T/G1764A double mutant in the basal core promoter (BCP) region of the hepatitis B virus (HBV) is associated with severe hepatic lesions while the G1899A mutation with the double mutant is associated with a significant reduction in the risk of severe fibrosis. This study aims to measure a number of markers in the serum of patients with chronic HBV infection and to assess relationships between these markers and BCP/precore mutants with consideration of the stage of fibrosis. The serum levels of resistin, TGF-β1, MMP-1, TIMP-1, collagen IA1 and PDGF-BB, which are markers that are known to be involved in the process of hepatic fibrosis, were assayed.
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