Publications by authors named "F Lugani"
Article Synopsis
- IgA vasculitis (IgAV) is a pediatric disease characterized by skin and systemic symptoms, and researchers conducted comprehensive studies involving genome, transcriptome, and proteome analyses on a large cohort of IgAV patients and controls to better understand the disease mechanisms.*
-
- Significant associations were found with specific genetic risk factors, including two novel non-HLA loci linked to IgA receptor functioning, which may contribute to disease development through altered immune responses.*
-
- Systems biology approaches helped identify key regulatory networks and master regulators in myeloid cells, along with 21 genetic loci that overlap with IgA nephropathy, suggesting shared pathways in these related conditions.*
Article Synopsis
- The study investigated the effectiveness and safety of rituximab for treating childhood steroid-resistant nephrotic syndrome (SRNS) across 28 pediatric nephrology centers globally.
- Researchers found that children with a longer history of calcineurin inhibitors (CNIs) treatment before rituximab had lower remission rates compared to those with shorter treatment periods.
- Overall, rituximab showed enhanced remission rates in a portion of SRNS patients, was mostly safe, and achieving complete remission was linked to better kidney survival outcomes.
Pediatr Nephrol
February 2025
Article Synopsis
- Hemolytic uremic syndrome (HUS) is a serious condition that can happen after an infection or due to problems in the body's immune system, and there are two types: typical and atypical.
- This text discusses a 9-year-old boy who had a rare form of aHUS caused by specific genetic issues, which made his body produce autoantibodies that affected his kidneys and brain.
- The study found that many kids with aHUS needed kidney treatment and that early treatment with special therapy may help prevent kidney failure, even if the patient has infections like STEC.
Kidney Int Rep
September 2024
Article Synopsis
- The study examines how various clinical, laboratory, and personal factors influence the choice and timing of kidney replacement therapy (KRT) among pediatric patients with chronic kidney disease (CKD).
- Researchers analyzed a cohort of 695 children aged 6 to 17 to identify what factors lead to either starting dialysis or receiving preemptive transplantation.
- Key findings show that kidney function decline, disease type, and other health indicators like blood pressure and hemoglobin levels significantly affect KRT decisions, with notable variations between different medical centers.
